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哺乳动物中,雌二醇E_2和黄体酮对子宫内胚泡的植入和胚泡的发育是必需的。抗雌激素的单独使用或与米非司酮联合应用在一定剂量上可有效地防止或终止大鼠的怀孕。本研究就是为了确定这些药物是否影响子宫的前列腺素(PGF_(2α)和PGE_2的浓度。采用了三种动物模型:(1)切除卵巢的大鼠。(2)性交后的大鼠。(3)植入后怀孕的大鼠。试验用的药物有anordiol(5mg/kg/d),他莫昔芬,RU 39411,米非司酮(4mg/kg/d)。均被溶解在最小容量的100％乙醇中悬浮在玉米油中,并通过管饲法给大鼠口服。ICI 182780,17β-雌二醇被溶解在最小量的乙醇中,
In mammals, estradiol E2 and progesterone are essential for intrauterine blastocyst implantation and blastocyst development. Antiestrogen alone or in combination with mifepristone at a dose can effectively prevent or stop the pregnancy in rats. The aim of this study was to determine whether these drugs affect uterine prostaglandin levels (PGF_ (2α) and PGE_2.) Three animal models were used: (1) Ovariectomized rats, (2) ) Pregnant rats were implanted with anordiol (5 mg / kg / d), tamoxifen, RU 39411 and mifepristone (4 mg / kg / d), all of which were dissolved in a minimum volume of 100% ethanol was suspended in corn oil and orally administered to rats by ICG 182780. The 17β-estradiol was dissolved in a minimum amount of ethanol,