过敏性紫癜(HSP)是儿童多发病之一,绝大多数预后良好,肾脏受累演变为永久性肾脏损害者为1％～20％,肾功能衰竭引起的死亡率为0.37％～3％。但肾脏受累能否早期诊断,及时治疗,从而减少死亡率尚少见报告。我们采用放射免疫分析法(RIA)测定血、尿β_2微球蛋白(β_2MG)量变化作为紫癜肾早期诊断,动态观察与估计预后的指标,现将结果分析报告如下。 1 资料和方法 1.1 临床资料:病例为1995年10月同期收治的过敏性紫癜11例,男4例,女7例。紫癜肾炎2例,紫癜肾病6例,年龄4～11岁。8例肾脏受累者按Meddow分 Henoch-Schonlein purpura (HSP) is one of the most frequently-occurring childhood diseases, with the vast majority of patients with a favorable prognosis. Renal involvement evolves to 1% to 20% for permanent kidney damage and 0.37% to 3% for renal failure. However, whether the early diagnosis of kidney involvement, timely treatment, thereby reducing the mortality rate is still rare report. We use radioimmunoassay (RIA) determination of blood and urine β 2 microglobulin (β 2 MG) changes as the early diagnosis of purpura nephritis, dynamic observation and prognosis of the indicators, the results are reported as follows. 1 Materials and Methods 1.1 Clinical data: the case of the same period in October 1995 admitted 11 cases of Henoch-Schonlein purpura, 4 males and 7 females. Purpura nephritis in 2 cases, purpura nephropathy in 6 cases, aged 4 to 11 years. 8 cases of kidney involvement by Meddow points