论文部分内容阅读
目的:探讨妊娠早期孕妇血清中ADAM12-S水平变化与异位妊娠的关系。方法:选取2010年7月至2011年5月就诊于我院的60例异位妊娠孕妇(研究组),120例正常单胎妊娠孕妇(对照组),于5～9孕周应用时间分辨荧光免疫分析法检测其血清中ADAM12-S水平,并分析ADAM12-S水平与异位妊娠的关系。结果:①120例正常对照组孕妇5、6、7、8、9孕周血清中AD-AM12-S水平分别为6.80±0.56、17.45±1.22、40.24±2.72、88.64±5.31、162.42±15.78μg/L,总体趋势是随孕周的增加而增加,且明显的线性关系,相关系数(r)为0.898(P<0.05)。②60例研究组孕妇血清ADAM12-S水平一直处于低值状态,且随着孕周的增加变化不明显,甚至有所降低,未呈现线性关系,r为0.064(P>0.05)。③研究组各孕周的中位数倍数明显低于正常对照组,差异有高度统计学意义(P<0.01)。结论:异位妊娠孕妇血清ADAM12-S水平明显低于正常单胎妊娠者,可以作为异位妊娠早期诊断的指标之一,检测血清ADAM12-S水平可提高异位妊娠的早期诊断率。
Objective: To investigate the relationship between ADAM12-S level and ectopic pregnancy in pregnant women in early pregnancy. Methods: Totally 60 ectopic pregnant women (study group) and 120 normal singleton pregnancy pregnant women (control group) were enrolled in our hospital from July 2010 to May 2011. The time-resolved fluorescence The level of ADAM12-S in serum was detected by immunoassay, and the relationship between ADAM12-S level and ectopic pregnancy was analyzed. Results: (1) The levels of AD-AM12-S in the pregnant women of 620 normal pregnant women on the 6th, 7th, 8th and 9th weeks were 6.80 ± 0.56,17.45 ± 1.22,40.24 ± 2.72,88.64 ± 5.31,162.42 ± 15.78μg / L, the overall trend was increased with the increase of gestational age, and a clear linear relationship, the correlation coefficient (r) was 0.898 (P <0.05). The level of ADAM12-S in pregnant women in the 60 study groups remained low at all times, and the serum ADAM12-S level did not change significantly with gestational age. The linear relationship was not found, r = 0.064 (P> 0.05). ③ The median of gestational weeks in the study group was significantly lower than that of the normal control group, the difference was highly statistically significant (P <0.01). Conclusion: The level of serum ADAM12-S in ectopic pregnancy is significantly lower than that in normal single-pregnancy, which can be used as one of the indicators of early diagnosis of ectopic pregnancy. Detecting serum ADAM12-S level can improve the early diagnosis rate of ectopic pregnancy.