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目的观察阿托品联合盐酸戊乙奎醚(长托宁)在急性有机磷农药中毒中的疗效。方法 92例急性有机磷中毒患者,随机分为联合组(29例)、阿托品组(36例)和长托宁组(27例)。观察三组患者阿托品化时间、中毒症状消失时间、胆碱脂酶(CHE)恢复时间、治愈率及病死率。记录发生的不良反应。结果联合组患者在阿托品化时间、中毒症状消失时间、CHE恢复时间、治愈率及病死率方面明显优于阿托品组和长托宁组,差异有统计学意义(P<0.05)。联合组不良反应与其他两组比较,差异无统计学意义(P>0.05)。结论阿托品联合长托宁治疗有机磷中毒较阿托品疗效好,不良反应发生率低,死亡率降低,临床可积极采用治疗。
Objective To observe the curative effect of atropine and penehyclidine hydrochloride in acute organophosphorus pesticide poisoning. Methods A total of 92 patients with acute organophosphate poisoning were randomly divided into combined group (29 cases), atropine group (36 cases) and penehyclidine group (27 cases). The atropisol time, the time of poisoning, the recovery time of cholinesterase (CHE), the cure rate and the mortality rate were observed in the three groups. Record the occurrence of adverse reactions. Results The patients in the combination group were significantly better than the atropine group and the longitroline group in atropisol time, the time of poisoning disappearance, the recovery time of CHE, the cure rate and the mortality. The difference was statistically significant (P <0.05). Adverse reactions in the combination group compared with the other two groups, the difference was not statistically significant (P> 0.05). Conclusion Atropine combined with penehyclidine treatment of organophosphate poisoning than atropine good effect, low incidence of adverse reactions, mortality decreased, the clinical treatment can be actively used.