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目的 探讨血小板衍生生长因子 (PDGF)在肺鳞状细胞癌 (肺鳞癌 )中的表达及意义。方法 应用免疫组织化学技术观察了PDGF A链和PDGF B链在 2 8例肺鳞癌中的表达 ,并与其在肺非特异性炎症组织中的表达相比较。结果 PDGF A链和PDGF B链的表达主要定位于肿瘤细胞胞浆、血管内皮细胞及平滑肌细胞 ,炎症组织的肺泡上皮细胞及血管平滑肌细胞少量表达。PDGF A链和PDGF B链在肺鳞癌中有显著表达。结论 PDGF A链和PDGF B链的过表达与肺鳞癌可能有关 ,未发现其过表达与肺鳞癌的病理分级存在相关性
Objective To investigate the expression and significance of platelet-derived growth factor (PDGF) in lung squamous cell carcinoma (squamous cell carcinoma). Methods The expression of PDGF A chain and PDGF B chain in 28 squamous cell carcinomas of the lung was observed by immunohistochemistry and compared with their expression in lung nonspecific inflammatory tissues. Results The expression of PDGF A chain and PDGF B chain mainly localized in the cytoplasm of tumor cells, vascular endothelial cells and smooth muscle cells, inflammatory alveolar epithelial cells and vascular smooth muscle cells. PDGF A chain and PDGF B chain were significantly expressed in squamous cell lung cancer. Conclusion The overexpression of PDGF A chain and PDGF B chain may be related to squamous cell carcinoma of the lung. No correlation was found between the overexpression of PDGF A chain and the pathological grade of squamous cell carcinoma