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目的探讨血清妊娠相关蛋白A(PAPP-A)诊断可疑异位妊娠(EP)的临床价值。方法对2006年12月至2007年6月唐山市妇幼保健院154例可疑EP患者,采用酶联免疫吸附法检测血清PAPP-A浓度,根据检测结果建立受试者工作特性曲线(ROC曲线),确定诊断可疑EP的最佳分界值。结果EP患者血清PAPP-A的含量明显低于早期宫内妊娠(UP),以PAPP-A55.4U/L作为界值,诊断EP的灵敏度87.0%,特异度为55.8%。结论PAPP-A可以作为一种诊断EP的标志物。
Objective To investigate the clinical value of serum pregnancy-associated protein A (PAPP-A) in the diagnosis of suspected ectopic pregnancy (EP). Methods From December 2006 to June 2007, 154 patients with suspected EP in Tangshan MCH hospital were enrolled in this study. Serum PAPP-A concentration was measured by enzyme-linked immunosorbent assay (ELISA), and the receiver operating characteristic curve (ROC curve) Determine the best cutoff value for diagnosing suspicious EPs. Results The serum levels of PAPP-A in patients with EP were significantly lower than those in patients with early pregnancy. The sensitivity and specificity of PAPP-A55.4U / L were 87.0% and 55.8%, respectively. Conclusion PAPP-A can be used as a marker for the diagnosis of EP.