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对山东省某地山区和平原的85名12岁以下健康儿童血清中13种微量元素和8项计划免疫相关指标进行了检测分析.结果表明:除镁以外的其它微量元素水平平原均高于山区;8项免疫指标也呈同一趋势.逐步回归分析表明,铜、铁、锌三种微量元素与免疫指标呈正相关,提示这些微量元素能促进抗体的形成,有利于提高人群免疫水平;而百日咳、脊灰Ⅰ型免疫指标与铅、镍、铬呈负相关,说明它们不利于抗体产生.提示儿童血清微量元素水平可影响预防接种效果.因此,应在保证疫苗质量和提高接种率的同时,提倡全面合理的膳食营养.
Thirteen trace elements and eight immune markers in sera of 85 healthy children under 12 years old in mountainous area and plain of a mountainous area in Shandong Province were tested and analyzed.The results showed that all trace elements except plain magnesium were higher than the mountain ; The eight immune indicators also showed the same trend. Stepwise regression analysis showed that copper, iron, zinc three kinds of trace elements and immune indicators were positively correlated, suggesting that these trace elements can promote the formation of antibodies is conducive to raising the population immunity; and pertussis, There was a negative correlation between the type I immune index of polio and lead, nickel and chromium, which indicated that they were not conducive to antibody production, suggesting that serum trace element levels in children may affect the vaccination effect. Therefore, we should advocate the vaccine quality and vaccination rate Comprehensive and reasonable dietary nutrition.