建立了高效液相色谱法测定依折麦布辛伐他汀片的溶出度。采用Inertsil ODS-3色谱柱,以25 mmol/L磷酸二氢钠溶液(用10%磷酸调至pH 4.0)-乙腈(49∶51)为流动相,检测波长231 nm。依折麦布和辛伐他汀在1.0~12.0?g/ml和2.0~24.0?g/ml浓度范围内线性关系良好;平均回收率为100.8%和100.5%,RSD为1.0%和1.2%。3批样品20 min内依折麦布和辛伐他汀的溶出度分别为101.5%、100.2%、101.9%和92.5%、90.9%、91.5%。 A high performance liquid chromatography was developed for the determination of dissolution of ezetimibe and simvastatin tablets. Using Inertsil ODS-3 column, the detection wavelength was 231 nm with 25 mmol / L sodium dihydrogen phosphate solution (adjusted to pH 4.0 with 10% phosphoric acid) -acetonitrile (49:51). Ezetimibe and simvastatin had good linearity over the 1.0 to 12.0 μg / ml and 2.0 to 24.0 μg / ml concentrations; with an average recovery of 100.8% and 100.5% with RSDs of 1.0% and 1.2%, respectively. The dissolution rates of ezetimibe and ezetimibe in three batches of samples were 101.5%, 100.2%, 101.9% and 92.5%, 90.9% and 91.5% respectively within 20 min.