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目的通过对山东省首次出现的2例人感染H7N9禽流感病例的调查分析,为制定人感染H7N9禽流感预防控制措施提供科学依据。方法 2013年4月采用流行病学、临床检查、血清学监测和Real-time PCR法进行分析和诊断。结果 2例确诊病例均无明显的病、死禽接触史,呈现出家庭聚集性,其他的密切接触者均未发现异常,结合基因序列分析,提示可能存在有限的人传人。结论 2例人感染H7N9病例的感染来源不明确,需加强不明原因肺炎监测和进一步研究有关危险因素。
OBJECTIVE: To provide a scientific basis for the development of human infection prevention and control measures for H7N9 avian influenza through investigation and analysis of two cases of H7N9 bird flu in Shandong Province. Methods In April 2013, epidemiology, clinical examination, serological surveillance and Real-time PCR were used for analysis and diagnosis. Results There was no obvious pathological history of the dead or dead birds in the two cases. Family aggregation was observed. No other close contacts were found abnormalities. Combined with sequence analysis, it suggested that there may be limited human transmission. Conclusions The sources of infection in 2 human cases of H7N9 infection were unclear. Monitoring of unexplained pneumonia and further study of risk factors were needed.