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用克山病区粮、按病区人民偏食生活特点喂养幼豚鼠证明:其血、肝、心等组织中的硒水平及谷胱甘肽过氧化物酶活性明显降低,作为机体氧应激反应(oxidative stress)虽可见超氧化物歧化酶的某些增强,但过氧化氢酶、谷胱甘肽转硫酶不仅未见活性增加,反而低于对照,同时可见红细胞膜中的共轭双烯、荧光色脂、肝及心肌线粒体、微粒体中的脂质过氧化物、氢过氧化物类均明显增加。表明组织,尤其膜系统受到明显的氧化损伤。心肌线粒体心磷脂含量及细胞色素氧化酶活性降低,代表酶二级构象的园二色性异常。讨论了克山病的病因发病机制:营养缺欠所致缺硒性氧应激障碍。
With Keshan ward food, according to the characteristics of the partial eclipse of the ward feeding young guinea pigs proved: the blood, liver, heart and other organizations in the selenium levels and glutathione peroxidase activity was significantly reduced as the body oxygen stress response (oxidative stress) Although some of the enhanced superoxide dismutase, but catalase, glutathione S-transferase activity was not only increased, but lower than the control, while visible in the erythrocyte membrane conjugated dienes , Fluorescent color lipids, liver and myocardial mitochondria, lipid peroxides in microsomes, hydroperoxides were significantly increased. This indicates that the tissue, especially the membrane system, is obviously oxidatively damaged. Myocardial mitochondrial cardiolipin content and cytochrome oxidase activity decreased, representing the secondary conformation of the park dichroism abnormalities. The pathogenesis of Keshan disease was discussed: lack of selenium-induced oxygen stress disorder caused by nutritional deficiencies.