患者女,48岁,因双侧膝关节疼痛、肿胀、屈伸不利、活动受限,于2002年4月3日来我院门诊就诊。经检查诊断为退行性骨关节炎。患者既往血压偏低,在85/60mmHg左右,有家族性低血压史,无药物过敏史,以往曾服用布洛芬、吲哚美辛、吡罗喜康及双氯芬酸钠等药治疗多年,无不良反应发生。遂给予双氯芬酸钠50mg,tid,天和骨通贴膏外敷,qd,治疗。患者于用药5天后,出现头昏、心悸、失眠、乏力等症状,再次来院就珍。查体:T The female patient, 48 years old, came to our hospital for outpatient treatment on April 3, 2002 because of bilateral knee pain, swelling, poor flexion and extension, and limited mobility. After examination diagnosed as degenerative osteoarthritis. Patients with low blood pressure in the past, about 85 / 60mmHg, history of familial hypotension, no history of drug allergies, ibid, indomethacin, piroxicam and diclofenac sodium and other drugs in the past for many years without adverse reactions . Then given diclofenac sodium 50mg, tid, days and Gutong paste topical, qd, treatment. 5 days after the patient medication, dizziness, palpitations, insomnia, fatigue and other symptoms, once again to Jane hospital. Physical examination: T