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In this paper,the control problem of distributed parameter systems is investigated by using wireless sensor and actuator networks with the observer-based method.Firstly,a centralized observer which makes use of the measurement information provided by the fixed sensors is designed to estimate the distributed parameter systems.The mobile agents,each of which is affixed with a controller and an actuator,can provide the observer-based control for the target systems.By using Lyapunov stability arguments,the stability for the estimation error system and distributed parameter control system is proved,meanwhile a guidance scheme for each mobile actuator is provided to improve the control performance.A numerical example is finally used to demonstrate the effectiveness and the advantages of the proposed approaches.