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适宜剂量的单一抗高血压药物平均能够降低血压10mmHg。许多高血压患者,包括三期高血压、合并靶器官损伤、或有发生心血管意外和(或)服用大剂量单一降压药物出现副作用的高风险患者,需联合用药以期达到良好血压控制目标(<140／90) mmHg。Zusman R对两项研究进行了回顾,即一项双盲、安慰剂对照试验(n=70)和一项基于社区的开放研究(n=491),分别入选其他药物未能控制高血压的患者和血压控制不满意的良性前列腺增生症(BPH)患者,加用多沙唑嗪(一种长效选择性α1受体阻滞剂)并观察其抗高血压疗效。结果显示,增加多沙唑嗪后,血压显著下降,同时血脂指标也得以改善。对于合并
The appropriate dose of a single antihypertensive drug can reduce blood pressure 10mmHg. Many hypertensive patients, including stage III hypertension, target organ damage, or those at high risk of developing cardiovascular events and / or taking large doses of a single antihypertensive drug need to be co-administered in order to achieve good blood pressure control goals <140/90) mmHg. Zusman R reviewed two studies, a double-blind, placebo-controlled trial (n = 70) and a community-based open-label study (n = 491) enrolled in patients with other drugs that failed to control hypertension And benign prostatic hyperplasia (BPH) patients with unsatisfied blood pressure control were treated with doxazosin, a long-acting selective α1-blocker, and observed for antihypertensive efficacy. The results showed that, after the increase of doxazosin, blood pressure decreased significantly, while lipid indicators have been improved. For the merger