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为了寄生虫病的实驗治疗,制备了一系列β-芳氧乙基季銨盐。带有各种不同取代基团的苯酚与二甲基或二乙基β-氯乙基胺在丙酮溶液中于无水碳酸鉀的作用下縮合,成为相应β-芳氧乙基二甲基或二乙基胺,后者也可由各該苯酚先与过量溴化乙烯縮合成1-芳氧基-2-溴乙烷,再与二甲胺或二乙胺作用制成。这些胺化合物再与碘甲烷、溴化苄或溴化对硝基苄共热,便成相应β-芳氧乙基季銨盐。对硝基苯基β-溴乙基硫醚与三甲胺縮合,生成对硝基苯巯乙基三甲基季銨盐。
For the experimental treatment of parasitic diseases, a series of β-aryloxyethyl quaternary ammonium salts were prepared. Phenols with a variety of different substituent groups are condensed with dimethyl or diethyl β-chloroethylamine in acetone solution under the action of anhydrous potassium carbonate to give the corresponding β-aryloxyethyl dimethyl or Diethylamine, which may also be formed by the condensation of each of the phenols with an excess of brominated ethylene to 1-aryloxy-2-bromoethane, with dimethylamine or diethylamine. These amine compounds are then co-heated with methyl iodide, benzyl bromide or p-nitrobenzyl bromide to form the corresponding beta-aryloxyethyl quaternary ammonium salt. Nitrophenyl β-bromoethyl sulfide and trimethylamine condensate, generating p-nitrophenyl mercaptoethyl trimethyl quaternary ammonium salt.