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中枢神经系统疾病分子改变的深入研究和基因治疗技术的不断发展为临床治疗这些疾病带来了希望。但基因治疗临床应用的最大障碍之一便是转基因技术中载体系统的选择。理想的体内基因转移载体应具有较好的细胞靶向性 ,目的基因表达的可控性以及转移方法的简单易行。自七十年代末?
In-depth study of molecular changes in CNS diseases and the continuous development of gene therapy technologies have brought hope for clinical treatment of these diseases. But one of the biggest obstacles to the clinical use of gene therapy is the choice of vector system in transgenic technology. The ideal in vivo gene transfer vector should have better cell targeting, the controllability of the gene of interest and the ease of transfer. Since the late seventies?