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肿瘤在形成和发展过程中涉及多种与能量代谢有关的蛋白，这些蛋白可能提供促进肿瘤生长的正向环境，也可能参与对肿瘤抵抗和清除的防御反应。α-烯醇化酶（ ENO1）作为一种多功能的蛋白，参与多种生理及病理过程，与肿瘤的发生、发展相关。研究发现，ENO1在头颈部肿瘤、呼吸系统肿瘤、消化系统肿瘤、妇科肿瘤及其他相关肿瘤中均有不同程度的表达。因此，ENO1可能成为预测某些肿瘤发生、发展、疗效及预后的辅助指标。“,”The formation and progression of tumors involves many proteins related to energy metabo-lism,which provides positive effect or has defensive reaction in the development and progression of the tumors.As a multifunctional protein,α-enolase is involved in a variety of processes,including physiological and pathological processes,and is also related with the development of some diseases,particularly in the tumor′s pathogenesis.Current study found that α-enolase is expressed in the tumors of head and neck ,re-spiratory,digestive,gynecologic system.Thus,α-enolase may become the auxiliary indicator of the occur-rence,development and prognosis of certain tumors.