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目的:分析多囊卵巢综合征(PCOS)患者血清游离脂肪酸(FFAs)水平的变化,并对其相关因素进行探讨。方法:将该院妇科收治的82例PCOS患者作为观察组,选择同时期的61例健康妇女作为对照组,对受试者的身高、腰围、体质量、实验室等相关指标进行统计、分析、对比。结果:观察组患者血清FFAs水平显著高于对照组,亦明显高于对照组中的两个体质量匹配组,比较差异均有统计学意义(P<0.05);相关因素分析:FFAs水平与受试者的腰围、体质量指数(BMI)、总胆固醇(TC)水平、低密度脂蛋白胆固醇(LDL-c)水平及总睾酮含量水平呈正相关(r=0.19、0.21、0.20、0.19、0.19、0.19,P<0.05),与高密度脂蛋白胆固醇(HDL-c)水平及稳态期120-180 min葡萄糖代谢率(M 120-180)呈负相关(r=-0.16、-0.21,P<0.05),与受试者年龄、空腹血糖(FPG)水平、空腹胰岛素(FINS)水平、三酰甘油(TG)水平及胰岛素抵抗指数(HOMA-IR)水平无相关性(r=0.02、0.08、0.13、0.12、0.11,P>0.05)。结论:PCOS患者血清FFAs水平会明显升高,且与患者的腰围、BMI及TC、LDL-c、总睾酮水平呈现正相关性。
Objective: To analyze the changes of serum free fatty acids (FFAs) levels in patients with polycystic ovary syndrome (PCOS) and to explore the related factors. Methods: A total of 82 PCOS patients admitted to our hospital were selected as the observation group. Sixty-one healthy women of the same period were selected as the control group. The subjects’ height, waist circumference, body weight, laboratory and other related indicators were statistically analyzed, Compared. Results: The serum FFAs levels in the observation group were significantly higher than those in the control group and significantly higher than those in the control group (P <0.05). Correlation analysis: FFAs levels were significantly different from those in the control group Waist circumference, body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c) and total testosterone were positively correlated (r = 0.19,0.21,0.20,0.19,0.19,0.19 , P <0.05), but negatively correlated with the level of HDL-c and glucose metabolism (120-180) at steady state (r = -0.16, -0.21, P <0.05 ) Had no correlation with age, fasting blood glucose (FPG), fasting insulin (FINS), triglyceride (TG) and insulin resistance index (HOMA-IR) , 0.12,0.11, P> 0.05). CONCLUSION: Serum FFAs levels in patients with PCOS are significantly increased, and positively correlated with waist circumference, BMI and TC, LDL-c and total testosterone in patients with PCOS.