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目的探讨妊娠期高血压疾病(HDCP)患者血浆氨基末端脑钠尿肽前体(NT-proBNP)及高敏C反应蛋白(hsCRP)与疾病严重程度的关系。方法选取2012年3月至2014年6月97例因妊娠期间初发高血压就诊患者为研究对象,按入院时病情分为重度子痫前期组(重度子痫前期患者33例)和非重度子痫前期组(妊娠高血压及轻度子痫前期患者64例),另外选取同期同孕周正常健康妊娠妇女60人为对照组。记录孕妇收缩压及舒张压水平,检测孕妇血浆NT-proBNP、hsCRP;将HDCP孕妇血浆NT-proBNP、hsCRP按照中位数分为两组,比较各组出现不同病情高血压疾病的构成比。结果与对照组比较,重度子痫前期组及非重度子痫前期组孕妇的血浆NT-proBNP、hsCRP水平、24h定量尿蛋白、收缩压、舒张压较高(均P<0.05),但重度子痫前期组与非重度子痫前期组间上述指标水平的差异无统计学意义(P>0.05)。与NT-proBNP≤263.6ng/L组比较,NT-proBNP>263.6ng/L组孕妇hsCRP水平较高(P<0.05),重度子痫前期构成比亦较高(P<0.05);与hsCRP≤6.83 mg/L组比较,hsCRP>6.83mg/L组孕妇血浆NT-proBNP水平较高(P<0.05),重度子痫前期构成比亦较高(P<0.05)。结论 HDCP患者血浆NT-proBNP、hsCRP水平随着病情发展不断升高,与重度子痫的发生密切相关。
Objective To investigate the relationship between the serum levels of NT-proBNP and hsCRP and the severity of the disease in patients with hypertensive disorders of pregnancy (HDCP). Methods From March 2012 to June 2014, 97 patients with newly diagnosed hypertension during pregnancy were enrolled in this study. The patients were divided into severe preeclampsia group (33 patients with severe preeclampsia) and non-severe Preeclampsia group (pregnancy-induced hypertension and mild preeclampsia in 64 patients), the other during the same period of pregnancy selected normal healthy pregnancy 60 women as the control group. The systolic blood pressure and diastolic blood pressure of pregnant women were recorded. The plasma NT-proBNP and hsCRP were detected in pregnant women. The plasma NT-proBNP and hsCRP levels of HDCP pregnant women were divided into two groups according to the median. The proportions of hypertensive disorders in different groups were compared. Results Compared with the control group, the levels of plasma NT-proBNP and hsCRP, 24h urinary protein, systolic pressure and diastolic blood pressure were higher in severe preeclampsia group and non-severe preeclampsia group (all P <0.05) There was no significant difference in the above indexes between preeclampsia group and non-severe preeclampsia group (P> 0.05). The levels of hsCRP in NT-proBNP> 263.6ng / L group were higher than those in NT-proBNP≤263.6ng / L group (P <0.05), and the proportions of severe preeclampsia were higher (P <0.05) The levels of NT-proBNP in pregnant women with hsCRP> 6.83 mg / L were significantly higher than those in the control group (6.83 mg / L) (P <0.05), and the proportions of severe preeclampsia were also higher (P <0.05). Conclusion The plasma levels of NT-proBNP and hsCRP in HDCP patients are increasing with the progression of the disease and closely related to the occurrence of severe eclampsia.