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目的 比较DPF与DBF两组方案治疗中晚期鼻咽癌的疗效和毒副作用。方法 3 4例患者接受DPF方案治疗 :DDP(顺铂 ) 40mg/m2 静脉滴注第 1～ 3天并水化 ,PYM(平阳霉素 ) 16mg肌注第 1,5天 ,5 -FU(5 -氟脲嘧啶 ) 60 0mg/m2 静脉滴注第 1～ 5天。另 3 1例接受DBF方案治疗 :DDP(顺铂 ) 40mg/m2 静脉滴注第 1～ 3天并水化 ,BLM(博莱霉素 ) 16mg肌注第 1,5天 ,5 -FU 60 0mg/m2 静脉滴注第 1～ 5天。均应用 2个周期。结果 两组方案治疗中晚期鼻咽癌的有效率差异无显著性 (DPF为 79% ,DBF为 84% ,P >0 0 5 ) ,患者都能耐受。结论 DPF与DBF方案均是治疗鼻咽癌的较佳方案。国产平阳霉素的疗效与进口博莱霉素的疗效相似 ,使用安全方便 ,价格便宜 ,毒副作用可耐受
Objective To compare the efficacy and side effects of DPF and DBF regimen in the treatment of advanced nasopharyngeal carcinoma. Methods 3 4 patients received DPF regimen: DDP (cisplatin) 40mg / m2 intravenous infusion 1 to 3 days and hydration, PYM 16mg intramuscular injection of 1,5 days, 5 -FU (5 - Fluorouracil) 60 0mg / m2 intravenous infusion of 1 to 5 days. The other 31 cases received DBF regimen: DDP (cisplatin) 40mg / m2 intravenously for 1 ~ 3 days and hydration, BLM (bleomycin) 16mg intramuscular injection on day 1, 5 -FU 60 0mg / m2 intravenous infusion of 1 to 5 days. Apply 2 cycles. Results There was no significant difference between the two groups in the treatment of advanced nasopharyngeal carcinoma (DPF 79%, DBF 84%, P 0 05). All patients were able to tolerate. Conclusions DPF and DBF regimens are the best treatment for nasopharyngeal carcinoma. Domestic Pingyangmycin efficacy and the efficacy of imported bleomycin similar to the use of safe and convenient, cheap, toxic and side effects can be tolerated