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目的观察中药金龙胶囊对慢性心力衰竭大鼠的长期疗效。方法行冠状动脉结扎术后5周的大鼠,经超声心动图评价,心力衰竭的诊断标准为左室射血分数(LVEF)≤45%,随机分为金龙胶囊治疗组10只,金龙胶囊治疗8周,行超声心动图及血流动力学检测,评估药物疗效;另10只心力衰竭大鼠为对照组。结果金龙胶囊组比对照组:①左室前壁收缩期厚度增加21.4%〔(1.7±0.3)mmvs(1.4±0.3)mm,P<0.05〕。左室后壁收缩期厚度增加68.8%〔(2.7±0.3)mmvs(1.6±0.4mm)P<0.001〕。②LVEF增加48.6%〔(52±14)vs(35±7),P<0.05〕。肺血管阻力指数降低20.3%〔(18.8±3.3)Vs(23.6±3.6),P<0.001〕。结论金龙胶囊可改善心力衰竭大鼠的收缩功能,增加左室压与主动脉压;并具有降低肺动脉压,降低肺血管阻力指数,降低右心负荷的作用,提示金龙胶囊可改善慢性心力衰竭大鼠的心功能,为临床用药提供了实验依椐。
Objective To observe the long-term efficacy of Chinese herbal medicine Jinlong capsule in chronic heart failure rats. Methods After 5 weeks of coronary artery ligation in rats, the diagnostic criteria of heart failure were left ventricular ejection fraction (LVEF) ≤ 45%, and were randomly divided into Jinlong capsule treatment group 10, Jinlong capsule treatment. At 8 weeks, echocardiography and hemodynamic testing were performed to assess the efficacy of the drug; another 10 rats with heart failure were the control group. Results Compared with the control group, the Jinlong capsule group had an increase of systolic thickness of the left anterior wall by 21.4% [(1.7±0.3) mmvs (1.4±0.3) mm, P<0.05]. The systolic thickness of the posterior wall of the left ventricle increased by 68.8% [(2.7 ± 0.3) mmvs (1.6 ± 0.4 mm) P <0.001]. 2LVEF increased by 48.6% ((52±14) vs (35±7), P<0.05). The pulmonary vascular resistance index decreased by 20.3% [(18.8 ± 3.3) Vs (23.6 ± 3.6), P <0.001]. Conclusion Jinlong capsule can improve the systolic function of rats with heart failure, increase left ventricular pressure and aortic pressure, and reduce pulmonary artery pressure, reduce pulmonary vascular resistance index, and reduce right heart load, suggesting that Jinlong capsule can improve chronic heart failure. Rat heart function provides experimental dependencies for clinical use.