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自Cohen等1960年在小鼠下颌下腺中检测出神经生长因子(NGF)和表皮生长因子(EGF)而获诺贝尔医学奖以来,人们在下颌下腺相继发现了转化生长因子、胰岛素、内皮素、白细胞介素等30余种生物活性物质。1994年 Mathison等提出颈交感干-颌下腺轴的新概念,国外学者对此十分关注,将其与下丘脑-脑垂体-内分泌腺轴相提并论。这再次证明下颌下腺不再像人们以往所了解那样仅有唾液腺消化功能,而是具有多方面的整合功能和调节作用。对下颌下腺功能进行深入研究,将丰富神经免疫内分泌科学的内涵。为证实唾液腺是否含与某些神经元、APUD细胞内相同的神经肽
Since Cohen et al. Obtained the Nobel Prize in Medicine in 1960 for detecting nerve growth factor (NGF) and epidermal growth factor (EGF) in the submandibular gland of mice, one has successively found transforming growth factor, insulin, endothelin and leukocyte in the submandibular gland Intermediates more than 30 kinds of bioactive substances. In 1994, Mathison et al proposed a new concept of cervical sympathetic stem-submandibular gland axis, which is very much concerned by foreign scholars and compared with hypothalamic-pituitary-endocrine axis. This once again proves that the submandibular gland is no longer as people only know as digestive function of salivary glands, but with a variety of integrated functions and regulatory role. In-depth study of submandibular gland function, will enrich the connotation of neuroendocrine endocrine science. To confirm whether the salivary gland contains the same neuropeptide as APUD cells in some neurons