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Objective:To investigate the expressions of GSK-3beta,Beta-catenin and PPAR-gamma,and their relationship in medulloblastoma,and to explore their value in clinic application. Methods:Immunohistochemical staining with SP method was conducted to determine the expressions of GSK-3beta,Beta-catenin and PPAR-gamma in 48 cases of medulloblastoma and 10 normal cerebellar tissues. Results:The rate of abnormal expressions of beta-catenin and PPAR-gamma in MB was higher than that in normal. Conversely,GSK-3beta in MB was lower than that in the normal (P<0.05). Furthermore,in medulloblastoma,beta-catenin and GSK-3beta showed a negative correlation,PPAR-gamma and beta-catenin had a positive correlation. Conclusion:Abnormal expression of beta-catenin plays a crucial role in the development of medulloblastoma. Meanwhile,PPAR-gamma and GSK-3beta which are tightly related with beta-catenin are both involved in the genesis and development of medulloblastoma.
Objective: To investigate the expressions of GSK-3beta, Beta-catenin and PPAR-gamma, and their relationship in medulloblastoma, and to explore their value in clinic application. Methods: Immunohistochemical staining with SP method was conducted to determine the expressions of GSK- 3beta, Beta-catenin and PPAR-gamma in 48 cases of medulloblastoma and 10 normal cerebellar tissues. Results: The rate of abnormal expressions of beta-catenin and PPAR-gamma in MB was higher than that in normal. Conversely, GSK-3beta in In addition, a positive correlation between PPAR-gamma and beta-catenin had a positive correlation. Conclusion Abnormal expression of beta- catenin plays a crucial role in the development of medulloblastoma. Meanwhile, PPAR-gamma and GSK-3beta which are closely related with beta-catenin are are involved in the genesis and development of medulloblastoma.