用H_2O_2引起软骨细胞的损伤,轻者软骨细胞出现空泡变、胞质致密化、核凝集成团等变化。重者软骨细胞坏死、溶解、正常结构不复存在,仅残留一些膜性小泡。加Zn~(2+)培养和Zn~(2+)保护(Zn~(2+)+H_2O_2)组软骨细胞仍保持较正常的超微结构,引起的损伤较轻。表明H_2O_2Zn~(2+)对软骨细胞的生物膜系统有保护作用。 Chondrocyte injury was induced by H_2O_2, and vacuoles, cytoplasmic densification and nucleocapsular aggregation of light chondrocytes changed. Severe chondrocytes necrosis, dissolution, the normal structure no longer exists, leaving only some membranous vesicles. Chondrocytes maintained normal ultrastructure with Zn 2+ and Zn 2+ protection (Zn 2+ (2 +) + H 2 O 2 group), resulting in less damage. It shows that H 2 O 2 Zn 2+ has a protective effect on the biofilm system of chondrocytes.