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目的:探讨对HIV阳性孕产妇的新生儿予以HIV的阻断措施的临床效果。方法:设定阻断技术路线,对HIV阳性孕产妇根据孕期实施不同的阻断措施,并对采取完全阻断、不完全阻断及未采取阻断措施的新生儿HIV的阴性率进行比较分析。结果:2005年至2010年各年度有关HIV母婴阻断传播的咨询率逐年上升,HIV阳性检出率为0.3%～0.6%;共114名HIV阳性孕产妇,87例(76.3%)选择继续妊娠者中85例围生儿存活。87例中51例采用了完全阻断措施,其新生儿HIV阴性率为98.0%;29例予以不完全阻断措施,其新生儿HIV阴性率为72.4%;未采取阻断7例(1例失访),新生儿HIV阴性率为0。结论:根据孕期时间实施完全阻断措施可有效降低HIV母婴传播率,提高新生儿生存质量,对遏制婴儿和儿童人群艾滋病的传播有重要意义。
Objective: To investigate the clinical effect of blocking HIV in neonates with HIV-positive pregnant women. Methods: To set the technical block of blocking, to carry out different blocking measures to HIV-positive pregnant women according to pregnancy, and to analyze the negative rate of HIV in newborns with complete block, incomplete block and no blocking measure . Results: From 2005 to 2010, the consultation rate on the transmission of HIV maternal and infant block was increased year by year, and the positive rate of HIV was 0.3% ~ 0.6%. A total of 114 HIV-positive pregnant women and 87 patients (76.3%) continued to choose 85 cases of perinatal children survived. Among 87 cases, 51 cases were completely blocked. The neonatal HIV-negative rate was 98.0%. 29 cases were incompletely blocked and the neonatal HIV-negative rate was 72.4%. Seven cases were not blocked (1 case Lost to visit), neonatal HIV negative rate of 0. CONCLUSION: The complete blockage during pregnancy can effectively reduce the rate of mother-to-child transmission of HIV and improve the quality of life of neonates, which is of great significance in preventing the spread of AIDS among infants and children.