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吡喹酮对驱除组织和肠道吸虫和绦虫有效,已广泛用于抗血吸虫感染;阿苯达唑则为高效的广谱抗蠕虫药;两者合用可能增加对常见蠕虫混合感染的疗效和/或减少治疗费用。 本实验研究了禁食和进食者体内两药单用和合用的药物动力学。对禁食者的研究:9名健康男性禁食过夜后,口服吡喹酮40mg/kg,或阿苯达唑400mg/kg,或两药合用。服药后2h内不进食。试验按随机交叉设计进行,两种治疗时间相距7天。服药前和其后的0.25,0.5,0.75,1,1.5,2,3,4,6,8,12和24h
Praziquantel is effective in eradicating tissue and intestinal trematodes and tapeworms and is widely used in anti-schistosome infections; albendazole is a highly effective broad-spectrum anthelmintic; and the combination of the two may increase the efficacy and / Or reduce the cost of treatment. In this study, fasting and eating in the two drugs alone and in combination pharmacokinetics. Study on Fasting: 9 healthy men after overnight fasting, oral praziquantel 40mg / kg, or albendazole 400mg / kg, or a combination of both drugs. Within 2h after taking medicine do not eat. The trial was conducted in a randomized crossover design with two treatment days 7 days apart. 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 and 24 h before and after the administration