对氧磷酶(PON)是一类能催化水解磷酸酯键的芳香酯酶,能够水解高密度脂蛋白和低密度脂蛋白分子中的氧化型磷脂,具有抗氧化作用。PON活性异常与动脉粥样硬化发生密切相关,PON日益受到重视。随着临床和分子生物学的进展发现,PON的活性与多囊卵巢综合征及其并发症密切相关,但在国内尚未见报道。现就此研究进展作一综述。 Paraoxonase (PON) is a class of aromatic esterases that catalyze the hydrolysis of phosphate linkages. It hydrolyzes oxidized phospholipids in high-density lipoproteins and low-density lipoproteins and has antioxidant properties. PON activity is closely related to the occurrence of atherosclerosis, PON is increasingly valued. With the progress of clinical and molecular biology found that PON activity and polycystic ovary syndrome and its complications are closely related, but has not been reported in China. This article reviews the progress of this research.