论文部分内容阅读
目的:探讨人参皂苷Rb3对局灶性脑缺血-再灌注损伤大鼠脑组织中兴奋性氨基酸(EAA)含量的影响。方法:将大鼠随机分成6组:假手术组、模型组、血栓通注射液(XST)组及人参皂苷Rb320、40、80 mg/kg组;采用线栓法使大脑中动脉闭塞(MCAO)建立大鼠局灶性脑缺血模型,于造模24 h后进行行为学评分以及检测脑组织中谷氨酸(Glu)、天冬氨酸(Asp)含量。结果:人参皂苷Rb340、80 mg/kg能明显减轻脑缺血再灌注损伤大鼠的行为学评分,显著降低脑组织中谷氨酸(Glu)、天冬氨酸(Asp)的含量(与模型组比较P<0.05或P<0.01)。结论:人参皂苷Rb3对抗缺血性脑损伤,防止缺血时EAA的升高,从而发挥对脑损伤的保护作用。
Objective: To investigate the effect of ginsenoside Rb3 on the content of excitatory amino acid (EAA) in the brain tissue of rats with focal cerebral ischemia-reperfusion injury. Methods: The rats were randomly divided into 6 groups: sham operation group, model group, XST group and ginsenoside Rb320, 40, 80 mg / kg group. The middle cerebral artery occlusion (MCAO) The model of focal cerebral ischemia in rats was established. The behavioral score and the content of Glu and Asp in brain tissue were detected 24 h after model establishment. Results: Ginsenoside Rb340 and 80 mg / kg significantly reduced the behavioral scores of rats with cerebral ischemia / reperfusion injury and significantly decreased the content of glutamate (Glu) and aspartate (Asp) in brain tissue Compare P <0.05 or P <0.01). CONCLUSION: Ginsenoside Rb3 can prevent ischemic brain injury and prevent the increase of EAA during ischemia, and thus play a protective role on brain injury.