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目的:探讨右美托咪定对腹腔镜手术全身麻醉患者血流动力学及应激反应的影响。方法:选取2018年5－12月在解放军联勤保障部队第九〇三医院择期行腹腔镜手术全身麻醉患者98例，按照随机数字表法将患者分为D组50例、C组48例，D组患者于麻醉诱导前10 min以0.2 μg·kgn －1·hn －1速度持续泵入右美托咪定直至手术完毕，C组给予等容量0.9%氯化钠注射液。比较两组患者气腹时间、手术麻醉时间以及麻醉恢复时间，用药前(T0)、气管插管时(T1)、开始气腹即刻(T2)、拔除气管插管时(T3)及拔管后5 min(T4)的收缩压(SBP)、舒张压(DBP)及心率(HR)，各时间点血浆肾上腺素、去甲肾上腺素及皮质醇水平，以及两组不良反应发生情况。n 结果:两组患者气腹时间、手术麻醉时间及麻醉恢复时间差异均无统计学意义(均n P>0.05)。在T1～T3时刻C组患者SBP、DBP及HR均较T0时刻显著升高(均n P0.05)，T1～T3时刻C组患者的SBP、DBP及HR均显著高于D组(均n P<0.05)。T1～T4时刻，两组患者肾上腺素、去甲肾上腺素及皮质醇均较T0显著升高(均n P<0.05)，而D组患者T1～T4时刻肾上腺素、去甲肾上腺素及皮质醇水平均显著低于C组(均n P<0.05)。C组患者高血压发生率为33.33%(14/48)，显著高于D组的8.00%(4/50)(χn 2＝9.676，n P0.05). The SBP, DBP and HR in group C were significantly higher than those in group T0 at T1-T3 (alln P0.05), and the SBP, DBP and HR in group C were significantly higher than those in group D (alln P<0.05). The levels of adrenaline, norepinephrine and cortisol at T1-T4 in the two groups were significantly higher than those at T0 (alln P<0.05), while the levels of adrenaline, norepinephrine and cortisol at T1-T4 in group D were significantly lower than those in group C (alln P<0.05). The incidence of hypertension in group C[33.33%(14/48)] was significantly higher than that in group D[8.00%(4/50)] (χn 2=9.676, n P<0.05).n Conclusion:Continuous infusion of dexmedetomidine during laparoscopic general anesthesia can effectively enhance the hemodynamic stability of patients, reduce intraoperative stress response and reduce the incidence of intraoperative hypertension, which is worthy of clinical application.