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目的:了解高能聚焦超声治疗联合胸腺肽α_1对原发性肝癌免疫功能的影响。方法:将原发性肝癌患者146例,随机分为3组,即HIFU刀单纯治疗组、胸腺肽α_1单纯治疗组和HIFU刀+胸腺肽α_1联合治疗组。每组治疗前后分别检测患者T、NK指标并进行比较。结果:所有组治疗后CD4~+,NK细胞比例上升,HIFU刀+胸腺肽α_1联合治疗组治疗后CD4~+上升尤其明显,B细胞、CD8~+胞变化不大。结论:推测胸腺肽可能会通过增强细胞免疫的机制尤其Th细胞比例,增加HIFU刀对原发性肝癌的治疗效果。
OBJECTIVE: To investigate the effect of high-energy focused ultrasound treatment on thymosin α_1 on the immune function of primary liver cancer. Methods: One hundred and sixty-six patients with primary liver cancer were randomly divided into three groups: HIFU treatment group, thymosin α_1 treatment group and HIFU knife + thymosin α_1 treatment group. Before and after each treatment were detected in patients with T, NK indicators and compared. Results: The proportion of CD4 ~ + and NK cells in all the groups increased after treatment. The increase of CD4 ~ + in HIFU + thymosin α_1 group was more obvious than that in HIFU + thymosin α_1 group. The changes of B cells and CD8 + cells were not obvious. Conclusion: It is speculated that thymosin may increase the therapeutic effect of HIFU on primary liver cancer by enhancing the mechanism of cellular immunity, especially the proportion of Th cells.