绝经过渡期功能性子宫出血是由于下丘脑-垂体-卵巢轴功能失调所致。临床表现为月经频发,经血量多,经期延长,贫血及感染等。诊断性刮宫和子宫内膜病理学检查是最可靠的诊断依据。米非司酮既能作用于丘脑,又能直接作用于垂体,亦可作用于卵泡颗粒细胞,促其凋亡。米非司酮可使子宫螺旋动脉萎缩,诱导子宫内膜细胞凋亡,使子宫内膜萎缩。故米非司酮治疗绝经过渡期功能性子宫出血,近期疗效确切,不良反应小。 Functional bleeding during menopause is due to impaired hypothalamic-pituitary-ovarian axis function. Clinical manifestations of frequent menstruation, menstrual flow, menstrual prolongation, anemia and infection. Diagnostic curettage and endometrial pathology is the most reliable diagnostic basis. Mifepristone can act on the thalamus, but also directly on the pituitary gland, but also on the granulosa cells, promote apoptosis. Mifepristone can uterine spiral artery atrophy, induce apoptosis of endometrial cells, so that the endometrial atrophy. Therefore, mifepristone treatment of menopausal transition dysfunctional uterine bleeding, the recent curative effect, adverse reactions.