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目的 探讨中晚期原发性阴道癌临床治疗方法。方法 本组４０例原发性阴道癌，其中１４例采用放疗 加顺铂、５－ＦＵ及丝裂霉素三联全身化疗，２６例单行放疗。结果 总５年及１０年生存率分别为５５．７％和４３．２％。Ⅱ 期３年及５年生存率为７４．５％和６１．１％，Ⅲ期３年及５年生存率为６４．５％和５３．２％，Ⅱ期３年及５年生存率与Ⅲ 期比较Ｐ＜０．０５。Ⅲ期放化疗的完全缓解率及５年生存率分别为７８．６％和６７．１％，而单行放疗的完全缓解率和生 存率为３０．８％和４６．３％，前者均显著高于后者（Ｐ＜０．０５）。结论 原发性阴道癌的预后与期别及治疗方法有关。
Objective To investigate the clinical treatment of primary vaginal cancer. Methods 40 cases of primary vaginal cancer, including 14 cases of radiotherapy plus cisplatin, 5-FU and mitomycin triple systemic chemotherapy, 26 cases of single-line radiotherapy. Results The overall 5-year and 10-year survival rates were 55.7% and 43.2% respectively. The 3-year and 5-year survival rates of stage Ⅱ were 74.5% and 61.1% respectively. The 3-year and 5-year survival rates of stage Ⅲ were 64.5% and 53.2% respectively. The 3-year and 5-year survival rates Ⅲ phase comparison P <0.05. The complete remission rate and 5-year survival rate of stage Ⅲ radiotherapy and chemotherapy were 78.6% and 67.1% respectively, while the complete remission rate and survival rate of single-line radiotherapy were 30.8% and 46.3%, both of which were significantly higher In the latter (P <0.05). Conclusion The prognosis of primary vaginal cancer is related to the stage and treatment.