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目的 探讨脑血管疾病与神经肽Ｙ（ＮＰＹ）含量变化之间的关系。方法 用放射免疫分析法测定７７ 例脑出血及９０例脑梗死患者治疗前后血浆ＮＰＹ的浓度。结果 脑出血组：发病后１～３ 天与对照组比血浆ＮＰＹ含量无差异，发病７～１４ 天及２１～２８ 天含量较对照组显著升高（均Ｐ＜ ０．０１）；脑梗死组：发病后１～３天与对照组比血浆ＮＰＹ浓度明显增高（Ｐ＜ ０．０１），发病７～１４ 天及２１～２８天明显低于发病后１～３天（Ｐ＜ ０．０１），但与对照组比无差异（Ｐ＞ ０．０５）。结论 ＮＰＹ在脑出血及脑梗死的发病机理中可能起着重要作用。
Objective To investigate the relationship between cerebrovascular disease and neuropeptide Y (NPY) content changes. Methods Radioimmunoassay was used to determine plasma concentrations of NPY in 77 patients with cerebral hemorrhage and 90 patients with cerebral infarction before and after treatment. Results Cerebral hemorrhage group: Compared with the control group, there was no difference in plasma NPY level between 1 and 3 days after onset, and the content of NPY in 7 ~ 14 days and 21 ~ 28 days after onset were significantly higher than those in control group (all P <0.01) (P <0.01). Compared with the control group, the plasma NPY concentration was significantly increased from 1 to 3 days after onset and from 7 to 14 days and from 21 to 28 days after onset (P <0.01) , But no difference with the control group (P> 0.05). Conclusion NPY may play an important role in the pathogenesis of cerebral hemorrhage and cerebral infarction.