铁死亡( ferroptosis )是近来发现的一种铁依赖的非凋亡形式的调控性细胞死亡,其特征为细胞死亡过程中伴随着大量的铁离子聚集、脂质过氧化以及致死性活性氧累积.尽管大量研究表明铁死亡在人类疾病中具有重要作用,但其具体作用机制尚不清楚.本文综述了铁死亡的概念、特征以及铁死亡相关基因的研究进展.“,”Ferroptosis is an iron-dependent , non-apoptotic form of regulated cell death , which is characterized by cell death accompanied by a large accumulation of iron and lipid peroxidation . Although numerous studies have shown the importance of ferroptosis in human disorders , the mechanism underlying ferroptosis is still unclear . The concept and character , and research progress of genes involved in ferropto-sis are reviewed in this article .