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目前,肝病界已将肝硬化列为肝癌的癌前期病变,因此研究肝硬化向肝癌发生的转变过程及此转变过程中肝脏的各种生化因素等的改变,找出从肝硬化到肝癌质变的关键因素,从而研究出能阻断肝硬化发展到肝癌的药物是当前研究的热点之一。为了研究肝硬化和肝细胞肝癌发生发展的关系,许多学者设计了从肝硬化发生到肝癌的动物模型,本文就目前常用的这一动物模型作了综述。
Currently, liver disease has cirrhosis as a precancerous lesion of liver cancer, liver cirrhosis to study the transformation process and the changes in the liver during a variety of biochemical changes, find out from the liver cirrhosis to the qualitative change of liver cancer Therefore, it is one of the hot topics in the current research to study the drugs that can block the development of liver cirrhosis to liver cancer. In order to study the relationship between the development of liver cirrhosis and hepatocellular carcinoma, many scholars have designed animal models of liver cancer from cirrhosis to hepatocellular carcinoma. This article reviews the commonly used animal model.