论文部分内容阅读
三氮唑核苷(ribavirin,virazole)是一种广谱抗病毒的核苷化合物。上海第六制药厂于1976年合成原料,我厂于1978年用该厂原料研制成注射液,命名为三氮唑核苷注射液,经过两年来的临床使用已于1981年鉴定投产,经上海市新华医院、北京儿童医院、湖北医学院儿童研究所等10多个单位临床验证,证明本品用于治疗病毒性呼吸道感染和疱疹病毒有较好的疗效,而对小儿腺病毒肺炎的疗效尤佳(腺病毒肺炎治疗160例,总有效率76.3%)。目前我厂即将投入生产,在研制本品的同时,我们还对注射液的稳定性进行了探讨。配制方法 1.处方:三氮唑核苷 1000g 氯化钠 90g 蒸馏水 10000ml
Ribavirin (virazole) is a broad-spectrum antiviral nucleoside compound. Shanghai Sixth Pharmaceutical Factory in 1976 synthetic raw materials, I plant in 1978 with the plant raw materials developed injection, named ribavirin injection, after two years of clinical use has been identified in 1981 put into operation by the Shanghai City Xinhua Hospital, Beijing Children’s Hospital, Institute of Children’s Hospital of Hubei Medical more than 10 units of clinical verification that the goods for the treatment of viral respiratory infections and herpes viruses have a good effect, and the efficacy of pediatric adenovirus pneumonia Good (adenovirus pneumonia treatment of 160 cases, the total efficiency of 76.3%). At present, I plant will soon put into production, in the development of this product at the same time, we also discussed the stability of injection. Preparation Method 1. Prescription: Ribavirin 1000g sodium chloride 90g distilled water 10000ml