人们对有机致癌物的探讨,为时已久。而无机致癌物却被忽视了若干年。早在1820年,有人报导,冶炼时,职业性接触砷引起阴囊癌。直到1880年,人们才注意到职业接触无机粉尘,烟雾,蒸汽与癌有关,但未进行动物实验。1936年,Bagg给公鸡睾丸内注射氯化锌,诱发了畸胎瘤。Schinz等(1942)给动物肌肉内植入金属,诱发了该部 People’s discussion of organic carcinogens, a long time. Inorganic carcinogens have been neglected for several years. As early as 1820, it was reported that occupational exposure to arsenic causes scrotal cancer when smelting. It was not until 1880 that people noticed that occupational exposure to inorganic dust, smoke and steam was related to cancer, but no animal experiments were conducted. In 1936 Bagg injected testicular zinc chloride into the cock and induced teratoma. Schinz et al. (1942) implanted metal into the animal’s muscle to induce this part