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在原发上皮肿瘤形成和生长的早期,肿瘤细胞便可以通过血流播散到远处器官。这些循环肿瘤细胞(circulating tumor cells,CTCs)可以通过不同技术进行富集和检测,其分析被认为是对癌症患者的实时“液体活检”。这种活检能对CTCs特异性亚群进行表征,且有可能为癌症的检测和控制带来革命性的转变。本篇作者将着重讨论当前用于CTCs富集和检测的策略。
In the early stages of primary epithelial tumor formation and growth, tumor cells can spread to distant organs by blood flow. These circulating tumor cells (CTCs) can be enriched and detected by different technologies and their analysis is considered as real-time “liquid biopsy” for cancer patients. This biopsy characterizes a specific subset of CTCs and may revolutionize the detection and control of cancer. The author of this article will focus on current strategies for enrichment and detection of CTCs.