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力复霉素是治疗结核、麻风等有效药物之一。近年来,随着新力复霉素衍生物的不断发展与临床滥用,又引起了新的问题一耐药性。国外研究证明,这类药物的耐药性与RNA多聚酶的突变有关,但耐药性与包膜屏障的关系至今尚无定论。本文用国产利福平(RFP)、利福定(R76—1)、环戊基哌嗪力复霉素SV(R77—3)通过同位素示踪、电镜和电镜自显影对细菌形态、结构、药物分布以及包膜组份等进行了突变耐药机理初步研究,结果简介于下:
Fructoolycin is one of the effective drugs for the treatment of tuberculosis and leprosy. In recent years, with the unceasing development and clinical abuse of the new compound, the new problem caused by drug resistance. Foreign studies have shown that drug resistance of these drugs and RNA polymerase mutations, but the relationship between drug resistance and the envelope barrier is still not conclusive. In this paper, the morphology, structure, structure and cell morphology of the bacteria were analyzed by isotope tracing, electron microscopy and electron microscopy with domestic rifampicin (RFP), rifamycin (R76-1) and cyclopentylpiperazinvirudin SV (R77-3) Drug distribution and envelope components such as a preliminary study of the mechanism of mutation resistance, the results summarized in the following: