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目的利用扩散张量成像(DTI)研究先天性耳聋(CD)患者的脑白质结构,探讨脑白质变化机制。方法对6名先天性耳聋患者和6名正常人进行脑部DTI扫描,应用基于体素的分析(VBA)对CD组和正常对照(HC)组的全脑分数各向异性(FA)值进行比较,计算样本感兴趣区(ROI)Brodmann(BA)41、BA22和BA44区的平均FA值。结果CD组FA值显著减少的区域位于右脑的颞上回(STG),ROI平均FA值除在右脑BA22区有下降的趋势外,未发现显著异常;CD组和HC组中左脑ROI的平均FA值显著偏大。结论先天性耳聋患者右脑STG白质损伤,这种结构异常是由其先天缺乏声音刺激所造成的。
Objective To study the white matter structure of patients with congenital deafness (CD) by diffusion tensor imaging (DTI) and to explore the mechanism of white matter changes. Methods DTI scanning of six patients with congenital deafness and six normal subjects was performed using the voxel-based analysis (VBA) for the whole brain fractional anisotropy (FA) of the CD group and the normal control (HC) group For comparison, calculate the mean FA values for Brodmann (BA) 41, BA22 and BA44 in the ROI of the sample. Results In the CD group, the area with significantly decreased FA value was located in the superior temporal gyrus (STG). The mean FA value of ROI was not significantly different except in the BA22 area of the right brain. The left ventricular ROI The average FA value was significantly larger. Conclusions STG white matter damage in the right brain of congenital deafness patients is caused by the congenital absence of sound stimulation.