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应用ELISA法检测42例急性尿路感染患者血清粒细胞集落刺激因子(G-CSF)水平,并动态观察了急性期(①)、应用抗菌药物治疗后第2天(②)及治愈后(③)的不同改变。结果上述3个时期血清G-CSF水平(x±s)分别为(1047.0±676.2)、(565.1±408.3)、(145.6±58.1)ng/L,25例对照组为(122.5±41.9)ng/L。统计分析表明:不同病程3个时期之间均存在极显著性差异(均P<0.01);①、②与对照组间差异也均具极显著性(均P<<0.01);③与对照组差别无统计学意义(P>0.05)。另外,急性期G-CSF水平与外周血中性粒细胞数呈正相关(r=0.48,P<0.05)。而不同感染部位和初诊时体温是否升高,G-CSF变化差异无显著性(均P>0.05)。
The levels of serum granulocyte colony stimulating factor (G-CSF) in 42 patients with acute urinary tract infection were detected by ELISA. The acute phase (①), the second day after treatment with antibiotics (②) and the ) Of the different changes. Results The levels of serum G-CSF in the three periods were (1047.0 ± 676.2), (565.1 ± 408.3) and (145.6 ± 58.1) ng / L, respectively. The control group was (122.5 ± 41.9) ng / L. Statistical analysis showed that there were significant differences (all P <0.01) between the three stages of different course of disease (P <0.01) The difference was not statistically significant (P> 0.05). In addition, the level of acute G-CSF was positively correlated with the number of peripheral blood neutrophils (r = 0.48, P <0.05). However, there was no significant difference in G-CSF between the different sites of infection and the initial diagnosis (all P> 0.05).