吗啡以及结构有关的镇痛药在医疗上应用已有多年,却只在近年才发现脑内有特异性的吗啡受体,并且还有内源性的激动剂与这受体结合。在激动剂中,Hughes首先分出二个五肽,称之为脑啡肽(Enkephalins),其组成分别为酪氨酰甘氨酰甘氨酰苯丙氨酰蛋氨 Morphine and structure-related analgesics have been used medically for many years but only in recent years have been found in the brain specific morphine receptors, and there are endogenous agonist binding to this receptor. Among the agonists, Hughes first separates two pentapeptides, called Enkephalins, which are composed of tyrosyl glycylglycylphenylalanine ammonia