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目的了解新生儿弥散性血管内凝血(DIC)急性期及恢复期血小板(PLT)及血小板生成素(TPO)水平的变化,为TPO在新生儿疾病中的临床应用提供依据。方法对30例DIC新生儿及35例足月健康新生儿采用血细胞分析仪检测PLT、血小板比积(PCT)、血小板平均体积(MPV);采用放射免疫法检测新生儿DIC急性期、恢复期及对照组的TPO水平。结果新生儿DIC急性期PLT(75±20)×109/L,MPV(6.0±1.5)fL,PCT(0.14±0.06)%,TPO(280±55)pg/L,与正常对照组比较有显著性差异。恢复期PLT(140±50)×109/L,MPV(8.5±0.5)fL,PCT(0.20±0.04)%,TPO(180±45)pg/L,与急性期比较PLT、MPV、PCT升高,TPO下降,差异显著,但与正常对照组比较亦有显著性差异,仍未完全恢复正常。结论新生儿DIC TPO显著升高,短期内不能恢复正常,与PLT破坏及造血功能不良有关。
Objective To investigate the changes of platelet (PLT) and thrombopoietin (TPO) levels in acute and convalescent neonates with disseminated intravascular coagulation (DIC) and provide basis for the clinical application of TPO in neonatal diseases. Methods PLT, thrombocytopenia (PCT) and mean platelet volume (MPV) were detected by hematology analyzer in 30 DIC neonate and 35 full-term healthy newborn. Radioimmunoassay was used to detect the acute phase, Control group TPO levels. Results Compared with the normal control group, the PLT (75 ± 20) × 109 / L, MPV (6.0 ± 1.5) fL, PCT (0.14 ± 0.06)% and TPO (280 ± 55) pg / Sex differences. The PLT (140 ± 50) × 109 / L, MPV (8.5 ± 0.5) fL, PCT (0.20 ± 0.04)% and TPO (180 ± 45) pg / L in the recovery phase were significantly higher than those in the acute phase , TPO decreased, the difference was significant, but compared with the normal control group also had significant differences, not fully returned to normal. Conclusions The neonatal DIC TPO is significantly elevated and can not recover to normal in the short term, which is related to the destruction of PLT and dysplasia of hematopoiesis.