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在Sprague-Dawley大鼠过敏性气道炎症模型上观察不同药物的抗炎作用。ip地塞米松(0.5mg·kg-1),粉防己碱(30mg·kg-1)以及非肽类神经速激肽受体拮抗剂CP-96345和SR-48968(各1mg·kg-1),每日2次,连续3d,可抑制卵白蛋白1mg致敏大鼠吸入抗原后6h或24h肺灌洗液中的白细胞数量增多,明显减轻细支气管和小血管周围嗜酸性细胞浸润及管壁水肿等炎症状况。结果证明大鼠模型可以作为评价平喘药作用的工具,并提示速激肽参与气道过敏性炎症。
Anti-inflammatory effects of different drugs were observed on an allergic airway inflammation model in Sprague-Dawley rats. ip dexamethasone (0.5 mg · kg -1), tetrandrine (30 mg · kg -1) and non-peptide tachykinin receptor antagonists CP-96345 and SR-48968 ), Twice a day for 3 consecutive days, can inhibit the ovalbumin 1mg sensitized rats inhaled antigen 6h or 24h lung lavage fluid leukocyte increased significantly reduce the bronchioles and small blood vessels around the eosinophil infiltration and wall Edema and other inflammatory conditions. The results show that the rat model can be used as a tool to evaluate the antiasthmatic effect and suggest that tachykinins are involved in airway allergic inflammation.