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目的:观察滋水平肝法合西药治疗高血压性肾损害的临床作用。方法:符合高血压性肾损害诊断标准的住院患者。按随机平行对照法分为两组,治疗组90例,西医治疗基础上加用滋水平肝饮中药,对治疗前后相关数据进行比较。结果:在高血压肾损害CKD1～4期(Ccr≥15ml/min)的患者中,治疗组的总有效率为82.28%,对照组总有效率为60.38%(P<0.01);在CKD5期(Ccr<15ml/min)的患者中,两组的显效不明显,但治疗组的有效率高于对照组,(P<0.05)。说明滋水平肝法为主治疗高血压性肾损害CKD1～4期的患者疗效显著优于西医治疗,对CKD5期的患者疗效亦好于单纯西医治疗,在一定程度上延缓了肾功能进展速度,推迟了透析开始时间。两组治疗后收缩压、舒张压均显著下降,差异显著(P<0.01),组间比较差异无显著性(P>0.05)。治疗组治疗后SCr、BUN、UA、Hgb、Ccr诸项,均获得了显著改善(P<0.01),且治疗后的上述指标治疗组较对照组均有显著差异(P<0.05,P<0.01)。结论:滋水平肝法可能有调节免疫功能,改善肾脏微循环,调节血管活性物质,减少尿蛋白,从而达到修复肾小管上皮细胞,改善肾小球功能,保护肾脏的作用。
Objective: To observe the clinical effect of zhejing pinggan fangxi western medicine on hypertensive renal impairment. Methods: Inpatients with diagnostic criteria for hypertensive renal impairment. According to the randomized parallel control method, the patients were divided into two groups. The treatment group was 90 cases. Based on the western medicine treatment, the traditional Chinese medicine was added to nourish the liver and calm the liver and drink Chinese herbs. The data before and after treatment were compared. Results: The total effective rate was 82.28% in treatment group and 60.38% in control group (P <0.01) in CKD stage 1-4 (Ccr≥15ml / min) Ccr <15ml / min), there was no obvious effect in both groups, but the effective rate of the treatment group was higher than that of the control group (P <0.05). The results showed that the therapeutic effect of nourishing Pinggan method on hypertensive renal damage CKD1 ~ 4 was significantly better than that of Western medicine, and the curative effect of CKD5 was better than that of Western medicine alone, which delayed the progress of renal function to a certain extent, Postponed dialysis start time. The systolic and diastolic blood pressures decreased significantly after treatment in both groups (P <0.01). There was no significant difference between the two groups (P> 0.05). The levels of SCr, BUN, UA, Hgb and Ccr in treatment group were significantly improved after treatment (P <0.01), and there was significant difference between the treatment group and the control group after treatment (P <0.05, P <0.01) ). Conclusion: Zifeng Pinggan method may regulate immune function, improve renal microcirculation, regulate vasoactive substances, reduce urinary protein, so as to repair renal tubular epithelial cells, improve glomerular function and protect the kidney.