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目的探讨微量元素锌对睡眠剥夺(SD)大鼠学习记忆的影响及其机制。方法用避暗法检测SD对大鼠学习记忆的影响,并用放射免疫法测定了不同脑区生长抑素和精氨酸加压素含量的变化。结果SD使大鼠学习记忆能力明显降低(P<0.01),同时下丘脑、海马和皮层等脑组织生长抑素和精氨酸加压素含量明显降低(P<0.05和0.01)。SD后补锌可使大鼠学习记忆功能及其海马中生长抑素和精氨酸加压素含量恢复到接近正常水平。结论锌对SD大鼠学习记忆功能具有保护作用,其机制可能是通过调节脑组织内源性生长抑素和精氨酸加压素代谢实现的。
Objective To investigate the effect of trace element zinc on learning and memory in sleep deprivation (SD) rats and its mechanism. Methods The effects of SD on learning and memory were examined by dark-avoidance method. The contents of somatostatin and arginine vasopressin in different brain regions were determined by radioimmunoassay. Results SD significantly reduced the learning and memory ability of rats (P <0.01), while the contents of somatostatin and arginine vasopressin in the hypothalamus, hippocampus and cortex decreased significantly (P <0.05 and 0.01). Zinc supplementation after SD can restore learning and memory ability of rats and the content of somatostatin and arginine vasopressin in normal rats. Conclusion Zinc has a protective effect on learning and memory in SD rats. The mechanism may be through regulating endogenous somatostatin and arginine vasopressin metabolism in brain.