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醛糖还原酶(AR)是促发鼠糖尿病性和半乳糖性白内障的共同因素。业已证明不同化学结构的AR抑制剂可以有效地延缓实验性糖性白内障的出现。最近报道AR抑制剂sorbinil基本上可以预防糖尿病性白内障的发生。作者等应用光镜研究了经sorbinil治疗半乳糖鼠的晶体,从而使AR抑制剂治疗糖性白内障的资料更为完善。方法:Sprague-Dawley白鼠,体重50克,用50%半乳糖饮食喂养。同时用插管经口内给予sorbinil,治疗剂量为60mg/kg/日。每天散瞳,用直接眼底镜及裂隙灯检查鼠晶体。分别在3,7,10,14,21天将鼠晶体取出进行组织学检查。结果:用半乳糖饮食喂养的鼠几乎均同时发
Aldose reductase (AR) is a common factor that triggers the development of diabetic and galactosyllabic cataracts. It has been demonstrated that AR inhibitors of different chemical structures can effectively delay the appearance of experimental glycated cataracts. Recently reported that AR inhibitor sorbinil can basically prevent the occurrence of diabetic cataracts. The authors studied the crystals of galactose treated with sorbinil using light microscopy, which made the data of AR inhibitor for treating cataract more perfect. METHODS: Sprague-Dawley rats weighing 50 g were fed a 50% galactose diet. At the same time by intubation with intubation sorbinil, a therapeutic dose of 60mg / kg / day. Mydriasis every day, with direct fundus and slit lamp check rat crystals. The rats were removed at 3, 7, 10, 14 and 21 days for histological examination. Results: Rats fed the galactose diet developed almost simultaneously