早在1934年,Fisher等对埃及血吸虫病流行区人群的研究发现,年龄与流行率/感染度之间存在“凸”线型关系,从而提出了人体存在与年龄相关的获得性免疫力的假说。而真正意义上的再感染研究始于1983年Sturrock等[1]对肯尼亚小学生化疗后感染曼氏血吸虫的观察,其研究结果引起了众多 As early as 1934, Fisher et al. Studied the population of endemic areas of schistosomiasis in Egypt and found that there was a “convex” linear relationship between age and prevalence / infectivity, thus proposing the hypothesis that the human body has age-related acquired immunity . The real sense of re-infection study began in 1983, Sturrock et al [1] on Kenyan primary school students infected with Schistosoma mansoni, the results of the study caused a large number