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目的 设计、制作可产生气道振荡的小型装置 ,并在体检测其对气道滞留物消除的影响。方法 利用空气动力学原理 ,通过调节呼气附加装置出气口角度、大小及盖口钢珠重量等方法 ,控制装置的频响范围 ,并应用于人体测试 ,呼吸道主要部位放置压力感受器 ,傅立叶分析方法分析共振频率和振幅。采用同位素标记气溶胶吸入后γ照像的方法 ,观察该装置对气道滞留物消除过程的影响。结果 该装置自身的频响范围为每秒 10～ 2 0次 ,应用于人体测得呼吸道从口咽部至肺叶支气管开口处的共振频率为每秒 13～ 14次 ,呼气时气道压力为 18～ 2 3cmH2 O ,压力振荡幅度为 1～ 2 .3cmH2 O。使用该装置可明显缩短气道内放射性气溶胶的半数消除时间。结论 该小型呼气附加装置的使用 ,可增加气道壁的震荡 ,改善气流特点 ,促进气道滞留物的消除 ,可望成为慢性阻塞性肺疾患 (COPD)气道粘液高分泌患者方便、实用的促排痰工具
Objective To design and fabricate a small device that produces airway oscillations and examine in vivo the effects on airway retentions. Methods By using the principle of aerodynamics, the frequency response range of the device was controlled by adjusting the outlet angle and size of the expiratory attachment and the weight of the bead in the cover. The method was applied to the human body test, and the baroreceptor was placed in the main respiratory tract. The Fourier analysis Resonance frequency and amplitude. Isotope-labeled aerosol inhalation gamma imaging method to observe the device on the airway retentate elimination process. Results The device’s own frequency response range of 10 to 20 times per second, used in human respiratory tract measured from the oropharynx to the bronchial lobe resonance frequency of 13 to 14 times per second, expiratory airway pressure 18 ~ 2 3cmH2O, the pressure oscillation amplitude of 1 ~ 2 .3cmH2O. Using this device can significantly shorten the airway aerosol half the elimination time. Conclusion The use of this small expiratory device can increase the airway wall oscillation, improve the airflow characteristics and promote the elimination of airway retentions, which is expected to be a convenient and practical method for patients with chronic obstructive pulmonary disease (COPD) Phlegm and promote the tool