临床上常规收集的１６１例门诊癫痫患者苯妥英（ＤＰＨ）的每日剂量—稳态血药浓度数据２５８对，应用ＮＯＮＭＥＭ程序一步估算其群体药动学参数（ｍｅａｎｓａｎｄ、ｖａｒｉａｎｃｅｓ），并定量地分析体重、性别、合并用药对最大消除速率Ｖｍ（ｍｇ·ｄ－１），年龄对米－曼氏常数Ｋｍ（μｇ·ｍｌ－１）的影响。异性间ＤＰＨ的Ｖｍ无显著差异，群体特征病人（体重６０ｋｇ，年龄≥１５ａ，未合并用苯巴比妥、安定或硝基安定）的Ｖｍ为４３９ｍｇ·ｄ－１，Ｋｍ为６．２１μｇ·ｍｌ－１。体重对Ｖｍ的调整值为ＷＴ／６０的０．５７次方，合并用药时Ｖｍ增加８．４ｍｇ·ｄ－１，年龄＜１５ａ则Ｋｍ下降７％。 One hundred and eighty - five pairs of daily dose - steady state plasma concentrations of phenytoin (DPH) were routinely collected in 161 outpatients with clinical epilepsy. The population pharmacokinetic parameters (meansand, variances) were estimated in one step using the NONMEM program and the body weight , Sex, combined medication on the maximum elimination rate Vm (mg · d-1), age on the M - Mann’s constant Km (μg · ml-1). Vm of heterosexual DPH had no significant difference. The Vm of group characteristic patients (weight 60kg, age ≥15a, not combined with phenobarbital, diazepam or nitrazepam) was 439mg · d-1, Km was 6.21μg · ml -1. The adjusted value of body weight for Vm was 0.57th power of WT / 60, Vm increased 8.4mg · d-1 when combined with medication, Km decreased 7% when age <15a.