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本文利用高效液相色谱法对12名抽脂健康患者皮下注射利多卡因的血清、唾液及脂肪浓度进行了测定,探讨了血清与唾液中药物浓度的相关性,并比较了二者之间的药代动力学参数。患者的平均给药剂量为20mg/kg,单剂量给药。实验结果表明血清与唾液中药物浓度呈线性关系:r=0.8043(p<0.01),C_(血清)=0.3433C_(唾液)+0.2620(n=78).唾液与血清药物浓度比值为2.37±0.857(比值范围:1.02～4.09,n=78).测得血清及唾液药代动力学参数分别为:吸收速率常数(Ka)0.573±0.583h~(-1),0.478±0.270h~(-1);消除半衰期(t_(1/2)k)6.41±2.08h,5.68±1.76h;达峰时间(T_(max))6.63±1.46h,6.67±1.80h;峰浓度(C_(max))2.52±0.926μg/ml,6.31±2.30μg/ml.血清与唾液的动力学参数除峰浓度(C_(max))外,统计学上均无明显差异(P>0.05).患者被抽出脂肪的药物含量为给药总量的31.84%(20.69～47.90%).
In this paper, serum, saliva and fat concentrations of subcutaneous injection of lidocaine in 12 patients with liposuction were measured by high performance liquid chromatography (HPLC), and the correlation between serum and saliva concentrations was also discussed. Pharmacokinetic parameters. The average patient dose of 20mg / kg, a single dose. The experimental results showed that there was a linear relationship between the concentration of saliva and serum in the serum: r = 0.8043 (p <0.01), C (serum) = 0.3433C saliva +0.2620 (n = 78) .The salivary and serum drug concentration ratio was 2.37 ± 0.857 (Ratio range: 1.02-4.09, n = 78) .The pharmacokinetic parameters of serum and saliva were as follows: absorption rate constant (Ka) 0.573 ± 0.583h -1, 0.478 ± 0.270h -1 ); The elimination half-life (t_ (1/2) k) 6.41 ± 2.08h and 5.68 ± 1.76h; the peak time (T_ (max)) 6.63 ± 1.46h and 6.67 ± 1.80h; 2.52 ± 0.926μg / ml, 6.31 ± 2.30μg / ml.The serum and saliva kinetic parameters except the peak concentration (C max) were not significantly different (P> 0.05) Drug content for the administration of 31.84% (20.69 ~ 47.90%).